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Dosage/Direction for Use
Topical/Cutaneous As an antiseptic agent Adult: As soln containing cetrimide 0.15 mg/mL and chlorhexidine 1.5 mg/mL: To be used as directed by the product. |
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Contraindications
Not to be used in the eye, ear, mucous membrane or body cavities.
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Special Precautions
Prolonged and repeated use may increase risk of hypersensitivity reactions. Blood, soap, cotton or other organic matter may decrease antibacterial efficacy.
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Adverse Reactions
Repeated application may lead to skin irritation.
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Overdosage
Accidental ingestion may lead to nausea and vomiting, dyspnoea and cyanosis due to paralysis of the respiratory muscles, may also cause asphyxia, depression of the CNS with convulsions, hypertension and coma may occur. Treatment is supportive and includes gastric lavage with water and charcoal.
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Action
Cetrimide is a quaternary ammonium antiseptic; it has bactericidal activity against both gram-positive and gram-negative organisms. Chlorhexidine is an antimicrobial agent; it is active against a wide range of gram-negative and gram-positive vegetative bacteria, yeasts, dermatophyte fungi and lipophilic viruses.
Absorption: Chlorhexidine: Poorly absorbed through the skin. |
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Storage
Topical/Cutaneous: Store at room temperature.
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CIMS Class
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ATC Classification
D09AA12 - chlorhexidine ; Belongs to the class of ointment dressings with antiinfectives.
D08AC02 - chlorhexidine ; Belongs to the class of biguanide and amidine antiseptics. Used in the treatment of dermatological diseases. B05CA02 - chlorhexidine ; Belongs to the class of antiinfectives used as irrigating solutions. S01AX09 - chlorhexidine ; Belongs to the class of other antiinfectives. Used in the treatment of eye infections. D08AJ04 - cetrimide ; Belongs to the class of quaternary ammonium compound antiseptics. Used in the treatment of dermatological diseases. D11AC01 - cetrimide ; Belongs to the class of medicated shampoos. R02AA05 - chlorhexidine ; Belongs to the class of antiseptics used in throat preparations. S02AA09 - chlorhexidine ; Belongs to the class of antiinfectives used in the treatment of ear infections. A01AB03 - chlorhexidine ; Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth. S03AA04 - chlorhexidine ; Belongs to the class of antiinfectives used in ophthalmologic and otologic preparations. |
